Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis Academic Article uri icon

Overview

MeSH Major

  • Adenosine Triphosphate
  • Cardiolipins
  • Cytochromes c
  • Mitochondria
  • Oligopeptides

abstract

  • SS-31 selectively targeted cardiolipin and modulated its interaction with cytochrome c. SS-31 inhibited the cytochrome c/cardiolipin complex peroxidase activity while protecting its ability to serve as an electron carrier, thus optimizing mitochondrial electron transport and ATP synthesis. This novel class of cardiolipin therapeutics has the potential to restore mitochondrial bioenergetics for treatment of numerous age-related diseases.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3976619

Digital Object Identifier (DOI)

  • 10.1111/bph.12468

PubMed ID

  • 24134698

Additional Document Info

start page

  • 2017

end page

  • 28

volume

  • 171

number

  • 8