Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model Academic Article uri icon

Overview

MeSH Major

  • Atrial Fibrillation
  • Calcium
  • Ryanodine Receptor Calcium Release Channel
  • Sarcoplasmic Reticulum

abstract

  • RyR2-mediated SR Ca(2+) leak directly underlies the development of a substrate for sAF in CREM mice, the first demonstration of a molecular mechanism underlying AF progression and sAF substrate development in an experimental model. Our work demonstrates that the role of abnormal diastolic Ca(2+) release in AF may not be restricted to the generation of atrial ectopy but extends to the development of atrial remodeling underlying the AF substrate.

publication date

  • March 25, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4026172

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.113.006611

PubMed ID

  • 24398018

Additional Document Info

start page

  • 1276

end page

  • 85

volume

  • 129

number

  • 12