Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis. Academic Article uri icon

Overview

MeSH Major

  • Heart Failure
  • Inflammation
  • Myocardium
  • Phagocytes
  • Spleen
  • Ventricular Remodeling

abstract

  • Activation of mononuclear phagocytes is central to the progression of cardiac remodeling in HF, and heightened antigen processing in the spleen plays a critical role in this process. Splenocytes (presumably splenic monocytes and dendritic cells) promote immune-mediated injurious responses in the failing heart and retain this memory on adoptive transfer.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.113.301720

PubMed ID

  • 24186967

Additional Document Info

start page

  • 266

end page

  • 82

volume

  • 114

number

  • 2