Rapamycin: One drug, many effects Review uri icon

Overview

MeSH Major

  • Signal Transduction
  • Sirolimus
  • TOR Serine-Threonine Kinases

abstract

  • The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological diseases, and genetic disorders. Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases. Here we discuss its mechanism of action and highlight recent findings regarding the effects and limitations of rapamycin monotherapy and the potential utility of combination therapy with rapamycin.

publication date

  • March 4, 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3972801

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2014.01.001

PubMed ID

  • 24508508

Additional Document Info

start page

  • 373

end page

  • 9

volume

  • 19

number

  • 3