Osteosarcoma treatment - Where do we stand? A state of the art review Review uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Osteosarcoma

abstract

  • Long-term outcome for patients with high-grade osteosarcoma has improved with the addition of systemic chemotherapy, but subsequent progress has been less marked. Modern, multiagent, dose-intensive chemotherapy in conjunction with surgery achieves a 5-year event-free survival of 60-70% in extremity localized, non-metastatic disease. A major, as yet unsolved, problem is the poor prognosis for metastatic relapse or recurrence, and for patients with axial disease. This article reviews the current state of the art of systemic osteosarcoma therapy by focusing on the experiences of cooperative osteosarcoma groups. Also, we shed light on questions and challenges posed by the aggressiveness of the tumor, and we consider potential future directions that may be critical to progress in the prognosis of high-grade osteosarcoma.

publication date

  • May 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ctrv.2013.11.006

PubMed ID

  • 24345772

Additional Document Info

start page

  • 523

end page

  • 32

volume

  • 40

number

  • 4