IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model Academic Article uri icon

Overview

MeSH Major

  • CCAAT-Enhancer-Binding Protein-beta
  • Epidermis
  • Interleukin-17
  • Keratinocytes

abstract

  • The genes identified in IL-17-treated RHE are likely relevant to the IL-17 effects in psoriasis, since ixekizumab (anti-IL-17A agent) strongly suppressed the "RHE" genes in psoriasis patients treated in vivo with this IL-17 antagonist.

publication date

  • February 28, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3938679

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0090284

PubMed ID

  • 24587313

Additional Document Info

start page

  • e90284

volume

  • 9

number

  • 2