Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer Academic Article uri icon

Overview

MeSH Major

  • In Situ Hybridization, Fluorescence
  • Prostatic Neoplasms, Castration-Resistant
  • Receptors, Androgen

abstract

  • Small clonal foci of cancer containing high level gain of the androgen receptor (AR)-gene develop before hormone deprivation therapy. Their small size makes detection by TMA inefficient and suggests a higher prevalence than that reported herein. It is hypothesised that a large proportion of AR-amplified CRPCa could pre-date hormone deprivation therapy and that these patients would potentially benefit from early total androgen ablation.

publication date

  • March 18, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3960602

Digital Object Identifier (DOI)

  • 10.1038/bjc.2014.13

PubMed ID

  • 24481405

Additional Document Info

start page

  • 1655

end page

  • 62

volume

  • 110

number

  • 6