Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer
In Situ Hybridization, Fluorescence
Prostatic Neoplasms, Castration-Resistant
Small clonal foci of cancer containing high level gain of the androgen receptor (AR)-gene develop before hormone deprivation therapy. Their small size makes detection by TMA inefficient and suggests a higher prevalence than that reported herein. It is hypothesised that a large proportion of AR-amplified CRPCa could pre-date hormone deprivation therapy and that these patients would potentially benefit from early total androgen ablation.