RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: A human genome epidemiologic review and meta-analysis of observational studies Review uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid
  • Genetic Determinism
  • Methotrexate
  • Reduced Folate Carrier Protein

abstract

  • In these analyses of available data from observational studies, RFC1 80G>A was found to be associated with MTX efficacy, but not toxicity, in RA patients. This variant merits further prospective analysis as a potential predictor of MTX efficacy. Variability in the definitions of response in pharmacogenetic studies is a source of data heterogeneity that should be addressed.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/art.38331

PubMed ID

  • 24782176

Additional Document Info

start page

  • 1111

end page

  • 20

volume

  • 66

number

  • 5