MYC, MAX, and small cell lung cancer Article uri icon

Overview

MeSH Major

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • Carcinoma, Non-Small-Cell Lung
  • DNA Helicases
  • Lung Neoplasms
  • Nuclear Proteins
  • Small Cell Lung Carcinoma
  • Transcription Factors

abstract

  • In this issue of Cancer Discovery, Romero and colleagues identify somatic mutations and deletions of MAX, and also define what seem to be mutually exclusive alterations in MYC family members and other MYC-associated factors in small cell lung cancer. Taken together, these data highlight the importance of MYC signaling in small cell lung cancer and suggest possible avenues for therapeutic intervention.

publication date

  • January 2014

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-14-0069

Additional Document Info

start page

  • 273

end page

  • 4

volume

  • 4

number

  • 3