Inherited genetic susceptibility to multiple myeloma Review uri icon

Overview

MeSH Major

  • Genetic Predisposition to Disease
  • Multiple Myeloma

abstract

  • Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

publication date

  • January 2014

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/leu.2013.344

PubMed ID

  • 24247655

Additional Document Info

start page

  • 518

end page

  • 24

volume

  • 28

number

  • 3