Laser-scanning confocal microscopy Chapter uri icon


MeSH Major

  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 3
  • Melanoma
  • Polymorphism, Genetic
  • Promoter Regions, Genetic


  • Early detection is critical to the successful treatment and survival of patients with melanoma. A dermatologist's sensitivity in detecting melanoma by visual clinical examination is reported to be in the range of 65% to 80% [26, 42]. Dermoscopy, which provides a magnified image of a lesion, can improve diagnostic accuracy to as high as 85% for clinicians who are highly trained in the use of dermoscopy [8]. However, sensitivity is still unacceptably low for a life threatening disease. Therefore, development of non-invasive high-resolution techniques for imaging melanocytic lesions in situ in the patient is highly desirable since they may increase diagnostic accuracy. © 2007 Springer-Verlag.

publication date

  • December 2007



  • Book Chapter


Digital Object Identifier (DOI)

  • 10.1007/978-3-540-35106-1_5

Additional Document Info

start page

  • 39

end page

  • 46