BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint Review uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Basic-Leucine Zipper Transcription Factors
  • DNA-Binding Proteins
  • Pre-B Cell Receptors
  • Precursor Cells, B-Lymphoid

abstract

  • At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of V(H)-DJ(H) gene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia suppression.

publication date

  • March 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3943645

Digital Object Identifier (DOI)

  • 10.1016/j.it.2013.11.002

PubMed ID

  • 24332591

Additional Document Info

start page

  • 131

end page

  • 7

volume

  • 35

number

  • 3