Immune modulation in cancer with antibodies Review uri icon


MeSH Major

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • CTLA-4 Antigen
  • Melanoma
  • Neoplasms
  • Programmed Cell Death 1 Receptor


  • Ipilimumab is the prototypical immunomodulatory antibody, approved by the FDA in 2011 for advanced melanoma on the basis of survival benefit. Since that time, we have made significant strides in optimizing this therapy: we have characterized the spectrum of immune-related adverse events and learned how to mitigate them with treatment algorithms, discovered potential biomarkers of activity, and identified the potential synergy between checkpoint modulation and other therapeutic modalities. Recent phase I trials have established the efficacy and safety of next-generation checkpoint agents, including PD-1 and PD-L1 inhibitors, across multiple tumor types. Much work lies ahead in developing these next-generation checkpoint agents, testing them in combination, and determining how to integrate them into the treatment paradigms of various tumor types.

publication date

  • January 2014



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-092012-112807

PubMed ID

  • 24188664

Additional Document Info

start page

  • 185

end page

  • 202


  • 65