MLKL regulates necrotic plasma membrane permeabilization Academic Article uri icon

Overview

MeSH Major

  • Cell Membrane
  • Necrosis
  • Protein Kinases

abstract

  • Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.

publication date

  • February 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3915909

Digital Object Identifier (DOI)

  • 10.1038/cr.2014.8

PubMed ID

  • 24418759

Additional Document Info

start page

  • 139

end page

  • 40

volume

  • 24

number

  • 2