Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors
DNA Copy Number Variations
Loss of Heterozygosity
Neoplasms, Germ Cell and Embryonal
Polymorphism, Single Nucleotide
Frequent aberrations of CCND2 (12p13) and RB1 (13q14) suggest that Cyclin/CDK-RB-E2F pathway might play a critical role in the pathogenesis of intracranial GCTs. Frequent gain of PRDM14 (8q13) implies that transcriptional regulation of primordial germ cell specification might be an important factor in the development of this tumor.