Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Brain Neoplasms
  • DNA Copy Number Variations
  • Genome, Human
  • Loss of Heterozygosity
  • Neoplasms, Germ Cell and Embryonal
  • Polymorphism, Single Nucleotide

abstract

  • Frequent aberrations of CCND2 (12p13) and RB1 (13q14) suggest that Cyclin/CDK-RB-E2F pathway might play a critical role in the pathogenesis of intracranial GCTs. Frequent gain of PRDM14 (8q13) implies that transcriptional regulation of primordial germ cell specification might be an important factor in the development of this tumor.

publication date

  • April 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pbc.24833

PubMed ID

  • 24249158

Additional Document Info

start page

  • 593

end page

  • 600

volume

  • 61

number

  • 4