The roles of evolutionarily conserved functional modules in cilia-related trafficking. Review uri icon

Overview

MeSH Major

  • Cilia

abstract

  • Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.

publication date

  • December 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4016715

PubMed ID

  • 24296415

Additional Document Info

start page

  • 1387

end page

  • 97

volume

  • 15

number

  • 12