Cancer-associated changes in the expression of TMPRSS2-ERG, PCA3, and SPINK1 in histologically benign tissue from cancerous vs noncancerous prostatectomy specimens Academic Article uri icon

Overview

MeSH Major

  • Antigens, Neoplasm
  • Carrier Proteins
  • Oncogene Proteins, Fusion
  • Prostate
  • Prostatic Neoplasms

abstract

  • Although the expression of TMPRSS2-ERG, SPINK1, and PCA3 mRNA is higher or more frequently found in cancerous lesions, HBP tissues from patients with clinically localized PCa manifest molecular, mRNA level changes that are absent in cystoprostatectomy specimens lacking incidental PCa foci or infrequent in cystoprostatectomy specimens containing incidental PCa. If this finding is replicated, these molecular assays could be used to inform men with negative biopsy results about the likelihood of cancerous lesions in unsampled regions and hence the need for repeat biopsy.

publication date

  • February 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3905625

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2013.11.005

PubMed ID

  • 24468524

Additional Document Info

start page

  • 511.e1

end page

  • 7

volume

  • 83

number

  • 2