PAX2 and PAX8: Useful markers for metastatic effusions Academic Article uri icon

Overview

MeSH Major

  • Ascitic Fluid
  • Biomarkers, Tumor
  • PAX2 Transcription Factor
  • Paired Box Transcription Factors
  • Pericardial Effusion
  • Pleural Effusion, Malignant

abstract

  • PAX8 is more sensitive than PAX2 for metastatic effusions from müllerian carcinomas (100 vs. 35%), while also having a higher intensity of staining than PAX2. However, PAX2 and PAX8 are both highly sensitive and specific for RCCs. PAX2 and PAX8 are valuable diagnostic markers for metastatic müllerian carcinomas and RCCs in effusion cytology. PAX8 is superior for carcinomas of müllerian origin.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1159/000356426

PubMed ID

  • 24334997

Additional Document Info

start page

  • 60

end page

  • 6

volume

  • 58

number

  • 1