Autophagy-dependent metabolic reprogramming sensitizes tsc2-deficient cells to the antimetabolite 6-aminonicotinamide Academic Article uri icon

Overview

MeSH Major

  • 6-Aminonicotinamide
  • Autophagy
  • Multiprotein Complexes
  • Pentose Phosphate Pathway
  • TOR Serine-Threonine Kinases
  • Tumor Suppressor Proteins

abstract

  • This study provides proof-of-concept that therapeutic targeting of diseases with hyperactive mTORC1 can be achieved without the application of mTORC1 inhibitors.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4030750

Digital Object Identifier (DOI)

  • 10.1158/1541-7786.MCR-13-0258-T

PubMed ID

  • 24296756

Additional Document Info

start page

  • 48

end page

  • 57

volume

  • 12

number

  • 1