Trail-coated leukocytes that kill cancer cells in the circulation Academic Article Article uri icon

Overview

MeSH Major

  • Achievement
  • Motivation
  • Self Concept
  • Women, Working

abstract

  • Metastasis through the bloodstream contributes to poor prognosis in many types of cancer. Mounting evidence implicates selectin-based adhesive interactions between cancer cells and the blood vessel wall as facilitating this process, in a manner similar to leukocyte trafficking during inflammation. Here, we describe a unique approach to target and kill colon and prostate cancer cells in the blood that causes circulating leukocytes to present the cancer-specific TNF-related apoptosis inducing ligand (TRAIL) on their surface along with E-selectin adhesion receptor. This approach, demonstrated in vitro with human blood and also in mice, mimics the cytotoxic activity of natural killer cells and increases the surface area available for delivery of the receptor-mediated signal. The resulting "unnatural killer cells" hold promise as an effective means to neutralize circulating tumor cells that enter blood with the potential to form new metastases.

publication date

  • January 21, 2014

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1073/pnas.1316312111/-/DCSupplemental

PubMed ID

  • 24395803

Additional Document Info

start page

  • 930

end page

  • 5

volume

  • 111

number

  • 3