C-kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy Academic Article uri icon

Overview

MeSH Major

  • Aging
  • Cardiomyopathies
  • Hypoxia
  • Myoblasts, Cardiac
  • Proto-Oncogene Proteins c-kit
  • Stem Cell Factor
  • Stem Cell Niche

abstract

  • Our findings support the notion that strategies targeting CSC activation and growth interfere with the manifestations of myocardial aging in an animal model. Although caution has to be exercised in the translation of animal studies to human beings, our data strongly suggest that a pool of functionally competent CSCs persists in the senescent heart and that this stem cell compartment can promote myocyte regeneration effectively, partly correcting the aging myopathy.

publication date

  • January 3, 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3959163

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.114.302500

PubMed ID

  • 24170267

Additional Document Info

start page

  • 41

end page

  • 55

volume

  • 114

number

  • 1