Targeting metabolic scavenging in pancreatic cancer Article uri icon

Overview

MeSH Major

  • Acrylamides
  • Antineoplastic Agents
  • NAD
  • Pancreatic Neoplasms
  • Piperidines

abstract

  • Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.

publication date

  • January 2014

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-13-2570

Additional Document Info

start page

  • 6

end page

  • 8

volume

  • 20

number

  • 1