Species-specific molecular mechanisms establishing the dopamine neuronal phenotype
Nucleic Acid Conformation
Throughout the animal kingdom, dopamine neurons are used to regulate essential behaviors ranging from locomotion to odor detection. Specification and maintenance of the dopaminergic phenotype requires the coordinated transcription of a cassette of genes that are necessary for the function of dopamine neurons. Defining the molecular mechanisms that regulate transcription of this gene cassette in humans is central to understanding nervous system development as well as the etiology and pathology of dopamine-related diseases. However, our understanding of these molecular mechanisms in humans is based largely on studies conducted in animal models. This chapter reviews reports of species-dependent variation in the regulatory mechanisms that control dopaminergic gene cassette transcription in widely used animal models. These studies are important guides for understanding the limitations of different animal models that are used to investigate human dopamine neuron development and disease. © 2012 Nova Science Publishers, Inc.
Additional Document Info
has global citation frequency