SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer Academic Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Carcinoma, Renal Cell
  • Chromosomes, Human, Pair 5
  • Gene Dosage
  • Kidney Neoplasms

abstract

  • Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosome 14q, which includes HIF1A, and gain of chromosome 5q. The relevant target(s) on chromosome 5q is not known. Here, we show that 5q amplification leads to overexpression of the SQSTM1 oncogene in ccRCC lines and tumors. Overexpression of SQSTM1 in ccRCC lines promoted resistance to redox stress and increased soft agar growth, while downregulation of SQSTM1 decreased resistance to redox stress, impaired cellular fitness, and decreased tumor formation. Therefore, the selection pressure to amplify 5q in ccRCC is driven, at least partly, by SQSTM1.

publication date

  • December 9, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3910168

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2013.10.025

PubMed ID

  • 24332042

Additional Document Info

start page

  • 738

end page

  • 50

volume

  • 24

number

  • 6