The role of B-cells in heart failure. Review uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Heart Failure

abstract

  • Heart failure is a complex disease that has great impact on morbidity and mortality in the general population. No recent therapies have proven to be effective; however, the discovery of new potential pathophysiological mechanisms involved in heart failure expression and progression could offer novel therapeutic strategies. A number of studies have shown that the immune system may be a central mediator in the development and progression of heart failure, and here we describe how the B-cell and B-cell-mediated pathways play specific roles in the heart failure state. Therapies aimed at B-cells, either blocking antibody production or inactivating B-cell function, may suggest potential new treatment strategies.

publication date

  • January 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3600879

PubMed ID

  • 23519014

Additional Document Info

start page

  • 15

end page

  • 9

volume

  • 9

number

  • 1