Mining the epigenetic landscape in ALL Comment uri icon

Overview

MeSH Major

  • Chromatin
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Repressor Proteins

abstract

  • The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

publication date

  • January 2013

Research

keywords

  • Comment

Identity

Digital Object Identifier (DOI)

  • 10.1038/ng.2808

PubMed ID

  • 24165727

Additional Document Info

start page

  • 1269

end page

  • 70

volume

  • 45

number

  • 11