Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1 Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Cell Aging
  • Endothelium, Vascular
  • Hyperglycemia
  • Hypoglycemic Agents
  • Metformin
  • Sirtuin 1

abstract

  • HG-induced down-regulation of SIRT1 played a crucial role in diabetes-induced endothelial senescence. Furthermore, the protective effect of metformin against HG-induced endothelial dysfunction was partly due to its effects on SIRT1 expression and/or activity.

publication date

  • January 2014

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3904269

Digital Object Identifier (DOI)

  • 10.1111/bph.12496

PubMed ID

  • 24372553

Additional Document Info

start page

  • 523

end page

  • 35

volume

  • 171

number

  • 2