IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds.
Cyclic Nucleotide Phosphodiesterases, Type 6
Genetic Predisposition to Disease
Photoreceptor Cells, Vertebrate
Identification of the mutations responsible for these two early-onset retinal degenerations provides new large animal models for comparative disease studies and evaluation of potential therapeutic approaches for the homologous human diseases.