What a tangled web we weave: Emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Neoplasms
  • Phosphatidylinositol 3-Kinases
  • Signal Transduction

abstract

  • There are multiple ongoing clinical trials targeting the PI3K pathway members in several malignancies. This review summarizes the known mechanisms of resistance to targeting the PI3K pathway. Understanding of resistance mechanisms will help to inform more rational clinical trial design to optimize the clinical impact of targeting the PI3K pathway in cancer.

publication date

  • December 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3864542

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-13-0063

PubMed ID

  • 24265156

Additional Document Info

start page

  • 1345

end page

  • 54

volume

  • 3

number

  • 12