Targeted therapies for hepatocellular carcinoma Chapter uri icon


MeSH Major

  • Carcinoma, Hepatocellular
  • Liver Neoplasms


  • The liver's role in xenobiotic metabolism, i.e., the modification of drugs and toxic foreign compounds, has long served as a putated explanation for inherent drug resistance of hepatocellular carcinoma (HCC). Therefore, it does not come as a surprise that the initial discovery of the multiple-drug resistance gene (MDR) was in liver tissue [1], and hepatocyte cell lines are a natural reservoir for the study of drug resistance. © 2011 Springer Science+Business Media, LLC.

publication date

  • December 2011



  • Book Chapter


Digital Object Identifier (DOI)

  • 10.1007/978-1-60327-522-4_22

Additional Document Info

start page

  • 355

end page

  • 368