Targeted therapies for hepatocellular carcinoma
The liver's role in xenobiotic metabolism, i.e., the modification of drugs and toxic foreign compounds, has long served as a putated explanation for inherent drug resistance of hepatocellular carcinoma (HCC). Therefore, it does not come as a surprise that the initial discovery of the multiple-drug resistance gene (MDR) was in liver tissue , and hepatocyte cell lines are a natural reservoir for the study of drug resistance. © 2011 Springer Science+Business Media, LLC.
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