Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with peutz-Jeghers syndrome Academic Article uri icon

Overview

MeSH Major

  • Aromatase
  • Gynecomastia
  • Loss of Heterozygosity
  • Peutz-Jeghers Syndrome
  • Protein-Serine-Threonine Kinases
  • Testis

abstract

  • Loss of heterozygosity of the STK11 gene leads to an increase in aromatase expression associated with an increase in CRTC nuclear localization, thereby providing a mechanism whereby PJS results in increased endogenous estrogens in affected males.

publication date

  • December 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1210/jc.2013-2291

PubMed ID

  • 24037887

Additional Document Info

start page

  • E1979

end page

  • 87

volume

  • 98

number

  • 12