Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes Review uri icon

Overview

MeSH Major

  • Immunity, Innate
  • Inflammasomes
  • Phagocytes
  • Phagocytosis
  • Receptors, Pattern Recognition

abstract

  • A decade of work shows that the core function of phagocytosis in engulfment and destruction of microorganisms is only a small facet of the full spectrum of roles for phagocytosis in the immune system. The regulation of phagocytosis and its outcomes by inflammatory pattern recognition receptors (PRRs) is now followed by new studies strengthening this concept and adding further complexity to the relationship between phagocytosis and innate immune signaling. Phagocytosis forms the platform for activation of distinct members of the Toll-like receptor family, and even dictates their signaling outcomes. In many cases, phagocytosis is a necessary precedent to the activation of cytosolic PRRs and assembly of canonical and non-canonical inflammasomes, leading to strong pro-inflammatory responses and inflammatory cell death.

publication date

  • February 2014

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3932007

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2013.11.003

PubMed ID

  • 24556406

Additional Document Info

start page

  • 100

end page

  • 10

volume

  • 26

number

  • 1