Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis Academic Article uri icon

Overview

MeSH Major

  • Bacterial Proteins
  • Immunomodulation
  • Lipoproteins
  • Membrane Proteins
  • Models, Molecular
  • Mycobacterium tuberculosis
  • Transport Vesicles

abstract

  • Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

publication date

  • December 3, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3856836

Digital Object Identifier (DOI)

  • 10.1073/pnas.1320118110

PubMed ID

  • 24248369

Additional Document Info

start page

  • E4790

end page

  • 7

volume

  • 110

number

  • 49