Common and divergent functions of Beclin 1 and Beclin 2 Article uri icon

Overview

MeSH Major

  • Autophagy
  • Intracellular Signaling Peptides and Proteins
  • Receptors, G-Protein-Coupled

abstract

  • In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in multiple aspects, including their functional profile as well as the genomic organization of the respective loci.

publication date

  • December 2013

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/cr.2013.129

Additional Document Info

start page

  • 1341

end page

  • 2

volume

  • 23

number

  • 12