Frequent truncating mutations of STAG2 in bladder cancer Academic Article uri icon

Overview

MeSH Major

  • Antigens, Nuclear
  • Codon, Nonsense
  • Urinary Bladder Neoplasms

abstract

  • Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

publication date

  • December 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3875130

Digital Object Identifier (DOI)

  • 10.1038/ng.2800

PubMed ID

  • 24121789

Additional Document Info

start page

  • 1428

end page

  • 30

volume

  • 45

number

  • 12