Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways Academic Article uri icon

Overview

MeSH Major

  • Graft Rejection
  • Heart Transplantation
  • Histocompatibility Antigens
  • Immunosuppressive Agents
  • Multiprotein Complexes
  • TOR Serine-Threonine Kinases

abstract

  • Abrogation of CR in rat model system involves modulation of two mTOR pathways: a RAPA-sensitive mTORC1 pathway regulating cellular proliferation and a RAPA-insensitive mTORC2 pathway regulating T-cell motility. Selective targeting of T-cell actin cytoskeletal pathways shows potential for pathway-targeted immunosuppression therapies.

publication date

  • November 15, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e3182a2034f

PubMed ID

  • 23985719

Additional Document Info

start page

  • 782

end page

  • 90

volume

  • 96

number

  • 9