Large-scale brain dynamics in disorders of consciousness Review uri icon


MeSH Major

  • Brain
  • Brain Injuries
  • Brain Waves
  • Consciousness Disorders
  • Models, Neurological


  • Brain injury profoundly affects global brain dynamics, and these changes are manifest in the electroencephalogram (EEG). Despite the heterogeneity of injury mechanisms and the modularity of brain function, there is a commonality of dynamical features that characterize the EEG along the gamut from coma to recovery. After severest injury, EEG activity is concentrated below 1 Hz. In minimally conscious state during wakefulness, there is a peak of activity in the 3-7 Hz range, often coherent across the brain, and often also activity in the beta (15-30 Hz) range. These spectral changes likely result from varying degrees of functional deafferentation at thalamic and cortical levels. EEG-based indices of brain dynamics that go beyond these simple spectral measures may provide further diagnostic information and physiologic insights.

publication date

  • April 2014



  • Review



  • eng

PubMed Central ID

  • PMC3980494

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2013.10.007

PubMed ID

  • 24709594

Additional Document Info

start page

  • 7

end page

  • 14


  • 25