Pharmacological distinction between soluble and transmembrane adenylyl cyclases Academic Article uri icon


MeSH Major

  • Adenylyl Cyclases
  • Membrane Proteins


  • The second messenger cAMP is involved in a number of cellular signaling pathways. In mammals, cAMP is produced by either the hormonally responsive, G protein-regulated transmembrane adenylyl cyclases (tmACs) or by the bicarbonate- and calcium-regulated soluble adenylyl cyclase (sAC). To develop tools to differentiate tmAC and sAC signaling, we determined the specificity and potency of commercially available adenylyl cyclase inhibitors. In cellular systems, two inhibitors, KH7 and catechol estrogens, proved specific for sAC, and 2',5'-dideoxyadenosine proved specific for tmACs. These tools provide a means to define the specific contributions of the different families of adenylyl cyclases in cells and tissues, which will further our understanding of cell signaling.

publication date

  • December 2013



  • Academic Article



  • eng

PubMed Central ID

  • PMC3836311

Digital Object Identifier (DOI)

  • 10.1124/jpet.113.208496

PubMed ID

  • 24091307

Additional Document Info

start page

  • 589

end page

  • 98


  • 347


  • 3