"Flagellated" cancer cells propel anti-tumor immunity Academic Article uri icon

Overview

MeSH Major

  • Antigen Presentation
  • Endosomes
  • Phagosomes
  • Toll-Like Receptors

abstract

  • The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trigger two types of pattern recognition receptors (PRRs).

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3489752

Digital Object Identifier (DOI)

  • 10.4161/onci.20305

PubMed ID

  • 23162764

Additional Document Info

start page

  • 940

end page

  • 942

volume

  • 1

number

  • 6