Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis
Hypoxia-Inducible Factor 1, alpha Subunit
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
Undifferentiated pleomorphic sarcoma (UPS) is a commonly diagnosed and particularly aggressive sarcoma subtype in adults, which frequently and fatally metastasizes to the lung. Here, we show the potential use of a novel therapeutic target for the treatment of metastatic UPS, specifi cally the collagen-modifying enzyme PLOD2.