Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis Academic Article uri icon

Overview

MeSH Major

  • Cell Hypoxia
  • Collagen
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Minoxidil
  • Neoplasm Metastasis
  • Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
  • Sarcoma

abstract

  • Undifferentiated pleomorphic sarcoma (UPS) is a commonly diagnosed and particularly aggressive sarcoma subtype in adults, which frequently and fatally metastasizes to the lung. Here, we show the potential use of a novel therapeutic target for the treatment of metastatic UPS, specifi cally the collagen-modifying enzyme PLOD2.

publication date

  • October 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3822914

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-13-0118

PubMed ID

  • 23906982

Additional Document Info

start page

  • 1190

end page

  • 205

volume

  • 3

number

  • 10