Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor. Academic Article uri icon

Overview

MeSH

  • Academic Medical Centers
  • Administration, Cutaneous
  • Adolescent
  • Cryopreservation
  • Drug Therapy, Combination
  • Humans
  • Male
  • Retrospective Studies
  • Semen Preservation
  • Time Factors
  • Treatment Outcome

MeSH Major

  • Aromatase Inhibitors
  • Hormone Replacement Therapy
  • Klinefelter Syndrome
  • Nitriles
  • Sperm Retrieval
  • Spermatogenesis
  • Testosterone
  • Triazoles

abstract

  • To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT). Case series. Academic medical center. Ten patients with Klinefelter syndrome, aged 14-22 years, treated with testosterone replacement and aromatase inhibitor therapy for a period of 1-5 years before surgical sperm retrieval. Microsurgical testis sperm extraction with cryopreservation of harvested tissue. Presence of spermatozoa within testis tissue. Successful sperm retrieval in 7/10 patients (70%). Use of topical TRT did not appear to suppress spermatogenesis in adolescents with KS. It is uncertain whether sperm retrieval rates would be higher or lower without testosterone replacement in these young males. Sperm cryopreservation should be discussed in all KS adolescents who are either receiving or considering initiating TRT. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

publication date

  • October 2013

has subject area

  • Academic Medical Centers
  • Administration, Cutaneous
  • Adolescent
  • Aromatase Inhibitors
  • Cryopreservation
  • Drug Therapy, Combination
  • Hormone Replacement Therapy
  • Humans
  • Klinefelter Syndrome
  • Male
  • Nitriles
  • Retrospective Studies
  • Semen Preservation
  • Sperm Retrieval
  • Spermatogenesis
  • Testosterone
  • Time Factors
  • Treatment Outcome
  • Triazoles

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2013.06.010

PubMed ID

  • 23830150

Additional Document Info

start page

  • 970

end page

  • 974

volume

  • 100

number

  • 4