Basophils and allergic inflammation Review uri icon

Overview

MeSH Major

  • Basophils
  • Hypersensitivity, Immediate
  • Inflammation

abstract

  • Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. However, recent studies in human subjects and murine systems have shown that basophils perform nonredundant effector functions and significantly contribute to the development and progression of TH2 cytokine-mediated inflammation. Although the potential functions of murine and human basophils have provoked some controversy, recent genetic approaches indicate that basophils can migrate into lymphoid tissues and, in some circumstances, cooperate with other immune cells to promote optimal TH2 cytokine responses in┬ávivo. This article provides a brief historical perspective on basophil-related research and discusses recent studies that have identified previously unappreciated molecules and pathways that regulate basophil development, activation, and function in the context of allergic inflammation. Furthermore, we highlight the unique effector functions of basophils and discuss their contributions to the development and pathogenesis of allergic inflammation in human disease. Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation.

publication date

  • October 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3903395

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2013.07.046

PubMed ID

  • 24075190

Additional Document Info

start page

  • 789

end page

  • 801; quiz 788

volume

  • 132

number

  • 4