The Mayo Clinic Biobank: a building block for individualized medicine. Academic Article uri icon

Overview

MeSH

  • Adolescent
  • Adult
  • Advisory Committees
  • Aged
  • Blood Specimen Collection
  • Electronic Health Records
  • Female
  • Humans
  • Informed Consent
  • Male
  • Medical History Taking
  • Medical Record Linkage
  • Middle Aged
  • Minnesota
  • Patient Selection
  • Young Adult

MeSH Major

  • Databases, Factual
  • Precision Medicine

abstract

  • To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank. Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions. After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use. The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

publication date

  • September 2013

has subject area

  • Adolescent
  • Adult
  • Advisory Committees
  • Aged
  • Blood Specimen Collection
  • Databases, Factual
  • Electronic Health Records
  • Female
  • Humans
  • Informed Consent
  • Male
  • Medical History Taking
  • Medical Record Linkage
  • Middle Aged
  • Minnesota
  • Patient Selection
  • Precision Medicine
  • Young Adult

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4258707

Digital Object Identifier (DOI)

  • 10.1016/j.mayocp.2013.06.006

PubMed ID

  • 24001487

Additional Document Info

start page

  • 952

end page

  • 962

volume

  • 88

number

  • 9