Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
DNA Modification Methylases
Lymphoma, Large B-Cell, Diffuse
The problem of chemoresistant DLBCL remains the most urgent challenge in the clinical management of patients with this disease. We describe a mechanism-based approach toward the rational translation of DNMTIs for the treatment of high-risk DLBCL.