Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • DNA Methylation
  • Gene Dosage
  • Glioblastoma
  • Lymphocytes, Tumor-Infiltrating
  • Mutation

abstract

  • TILs were enriched in glioblastomas of the mesenchymal class, strongly associated with mutations in NF1 and RB1 and typical of histologies characterized by these mutations. Conversely, TILs were depleted in the classical class, EGFR-amplified, and homozygous PTEN-deleted tumors and rare in histologies characterized by these alterations.

publication date

  • September 15, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3865611

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-13-0551

PubMed ID

  • 23864165

Additional Document Info

start page

  • 4951

end page

  • 60

volume

  • 19

number

  • 18