Immunosuppressive drug therapy Review uri icon

Overview

MeSH Major

  • Immunosuppressive Agents
  • Transplantation Immunology

abstract

  • The first successful kidney transplantation between monozygotic identical twins did not require any immunosuppressive drugs. Clinical application of azathioprine and glucocorticosteroids allowed the transfer of organs between genetically disparate donors and recipients. Transplantation is now the standard of care, a life-saving procedure for patients with failed organs. Progress in our understanding of the immunobiology of rejection has been translated to the development of immunosuppressive agents targeting T cells, B cells, plasma cells, costimulatory signals, complement products, and antidonor antibodies. Modern immunopharmacologic interventions have contributed to the clinical success observed following transplantation but challenges remain in personalizing immunosuppressive therapy. © 2013 Cold Spring Harbor Laboratory Press; all rights reserved.

publication date

  • September 17, 2013

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3753725

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a015487

PubMed ID

  • 24003247

Additional Document Info

volume

  • 3

number

  • 9