Functional assays of drug-target engagement on circulating tumor cells captured from patient blood correlate with patient progression Conference Paper uri icon

Overview

MeSH Major

  • Microfluidic Analytical Techniques
  • Neoplastic Cells, Circulating
  • Prostatic Neoplasms

abstract

  • Chemotherapeutic treatment is limited by the heterogeneous and short-lived efficacy of therapy. Functional assays of tu-bulin bundling on microchip-captured circulating tumor cells (CTCs) in late-stage castrate-resistance prostate cancer are presented for the first time, and results are interpreted in the context of patient progression. Anti-PSMA capture leads to high capture rates of cells that remain functionally responsive to chemotherapies. These results point to the potential for microflu- idicallycaptured CTCs to inform clinical care in this patient population.

publication date

  • December 2011

Research

keywords

  • Conference Paper

Additional Document Info

start page

  • 2068

end page

  • 2070

volume

  • 3