Crosstalk between ER stress and immunogenic cell death Review uri icon

Overview

MeSH Major

  • Cell Death
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Neoplasms

abstract

  • Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin. The molecular pathways whereby some, but not all, cytotoxic agents promote bona fide ICD remain to be fully elucidated. Nevertheless, a central role for the endoplasmic reticulum (ER) stress response has been revealed in all scenarios of ICD described thus far. Hence, components of the ER stress machinery may constitute clinically relevant druggable targets for the induction of ICD. In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy.

publication date

  • August 2013

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.cytogfr.2013.05.001

PubMed ID

  • 23787159

Additional Document Info

start page

  • 311

end page

  • 8

volume

  • 24

number

  • 4