It Takes a CAD to Kill a Tumor Cell with a LMP Article uri icon

Overview

MeSH Major

  • Cell Transformation, Neoplastic
  • Enzyme Inhibitors
  • Lysosomes
  • Sphingolipids
  • Sphingomyelin Phosphodiesterase

abstract

  • Cancer cells display lysosome hypertrophy, secreting lysosomal hydrolases for tumor progression. Hypertrophy renders lysosomes fragile, increasing lysosomal membrane permeabilization (LMP) tendency. In this issue of Cancer Cell, Petersen and colleagues show that lysosomal sphingomyelin content determines LMP and cationic drugs displace acid sphingomyelinase from lysosomal membranes, increasing tumor LMP and death.

publication date

  • September 9, 2013

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2013.08.025

Additional Document Info

start page

  • 279

end page

  • 81

volume

  • 24

number

  • 3