Diffuse variant of lymphocyte-predominant Hodgkin lymphoma: A diagnostic challenge Academic Article uri icon


MeSH Major

  • Genes, Immunoglobulin Heavy Chain
  • Lymphoma, B-Cell
  • V(D)J Recombination


  • The diffuse variant of nodular lymphocyte-predominant Hodgkin lymphoma (D-LPHL) is exceedingly rare. Here we report a case of D-LPHL in a 35-year-old Caucasian female who presented with left cervical and right axillary lymphadenopathy. Histopathologic examination reveals large atypical lymphoid cells resembling lymphocyte-predominant (LP) cells in a background of reactive T cells, B cells, and histiocytes. Extensive immunohistochemical study demonstrates that these large atypical lymphoid cells express characteristic phenotype of LP cells including CD20, CD79a, BOB-1, OCT-2, BCL-6, and EMA and are negative for CD30 and fascin. The diffuse nature of the lymphoid proliferation is confirmed by negative CD21, CD23, and CD35 stains showing a complete lack of follicular dendritic cell meshworks. The associated T cell microenvironment shows increased CD57(+) T cells arranged into peritumoral cell rosettes. The diagnostic criteria of this case are discussed and a review of the literature about the differential diagnosis is provided. © 2012 Springer-Verlag.

publication date

  • September 2013



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/s12308-012-0162-8

Additional Document Info

start page

  • 145

end page

  • 150


  • 6


  • 3